The LC/MS quantification of vardenafil (Levitra®) in postmortem biological specimens final report
(Web-Based Document)

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Author
Johnson, Robert D.
Contributors
Lewis, Russell J.
Angier, Mike K.
United States. Office of Aerospace Medicine.
United States. Federal Aviation Administration.
Civil Aerospace Medical Institute.
Published
Washington, D.C. : Ft. Belvior, VA : Springfield, Va. : Federal Aviation Administration, Office of Aerospace Medicine ; Available to the public through the Defense Technical Information Center ; Available to the public through the National Technical Information Service, 2006.
Status
Available Online
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LocationCall NumberStatus
Web-based Documents or Files - World Wide WebXX(809729.1)Available Online

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http://purl.access.gpo.gov/GPO/LPS74559

Subjects

LC Subjects
Aircraft accidents -- Investigation -- United States.
Forensic toxicology -- United States.
Impotence.

More Details

Published
Washington, D.C. : Ft. Belvior, VA : Springfield, Va. : Federal Aviation Administration, Office of Aerospace Medicine ; Available to the public through the Defense Technical Information Center ; Available to the public through the National Technical Information Service, 2006.
Format
Web-Based Document
Physical Desc
i, 10 pages : digital, PDF file.
Language
English

Notes

General Note
Tile from title screen (viewed on Sept. 27, 2006).
General Note
"July 2006".
General Note
"DOT/FAA/AM-06/17."
General Note
Available online.
Bibliography
Includes bibliographical references (p. 10).
Description
During the investigation of aviation accidents, postmortem specimens from accident victims are submitted to the Federal Aviation Administration's Civil Aerospace Medical Institute (CAMI) for toxicological analysis. As new medications are introduced to the market and are subsequently used by aviation accident victims, CAMI's forensic toxicology laboratory is tasked with developing analytical methods for the determination of these compounds. This report presents a rapid and reliable method for the identification and quantitation of vardenafil (Levitra®) in biological specimens. This procedure utilizes sildenafil-d8, which structurally is closely related to vardenafil, as an internal standard for more accurate and reliable quantitation. The method incorporates solid phase extraction and LC/MS/MS and MS/MS/MS utilizing an atmospheric pressure chemical ionization ion trap mass spectrometer in the positive chemical ionization mode. Solid-phase extraction proved to be exceptionally efficient providing recoveries that ranged from 94-97%. The limit of detection for vardenafil was determined to be 0.19 ng/mL. The linear dynamic range for this compound was 0.39-200 ng/mL. This method was successfully applied to postmortem fluid and tissue specimens obtained from an aviation accident victim. This novel analytical procedure proved to be simple, accurate, and robust for the identification and quantitation of vardenafil in postmortem specimens.
Funding Information
Performed by FAA Civil Aerospace Medical Institute, Oklahoma City, OK, under approved task no.,AM-B-05-TOX-204
System Details
Mode of access: Internet from the Office of Aerospace Medicine web site. Address as of 9/27/06: http://www.faa.gov/library/reports/medical/oamtechreports/2000s/ media/200617.pdf; current access via PURL.

Citations

APA Citation, 7th Edition (style guide)

Johnson, R. D., Lewis, R. J., & Angier, M. K. (2006). The LC/MS quantification of vardenafil (Levitra®) in postmortem biological specimens: final report . Federal Aviation Administration, Office of Aerospace Medicine ; Available to the public through the Defense Technical Information Center ; Available to the public through the National Technical Information Service.

Chicago / Turabian - Author Date Citation, 17th Edition (style guide)

Johnson, Robert D, Russell J. Lewis and Mike K. Angier. 2006. The LC/MS Quantification of Vardenafil (Levitra®) in Postmortem Biological Specimens: Final Report. Federal Aviation Administration, Office of Aerospace Medicine ; Available to the public through the Defense Technical Information Center ; Available to the public through the National Technical Information Service.

Chicago / Turabian - Humanities (Notes and Bibliography) Citation, 17th Edition (style guide)

Johnson, Robert D, Russell J. Lewis and Mike K. Angier. The LC/MS Quantification of Vardenafil (Levitra®) in Postmortem Biological Specimens: Final Report Federal Aviation Administration, Office of Aerospace Medicine ; Available to the public through the Defense Technical Information Center ; Available to the public through the National Technical Information Service, 2006.

MLA Citation, 9th Edition (style guide)

Johnson, Robert D., Russell J Lewis, and Mike K Angier. The LC/MS Quantification of Vardenafil (Levitra®) in Postmortem Biological Specimens: Final Report Federal Aviation Administration, Office of Aerospace Medicine ; Available to the public through the Defense Technical Information Center ; Available to the public through the National Technical Information Service, 2006.

Note! Citations contain only title, author, edition, publisher, and year published. Citations should be used as a guideline and should be double checked for accuracy. Citation formats are based on standards as of August 2021.

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